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pentobarbital will lower the level or effect of nilotinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital will reduce the extent or influence of eltrombopag by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Observe.benzhydrocodone/acetaminophen and pentobarbital both equally boost sedation.